Lipu Jie, Lijuan Niu, Tingting Lu, Qing Sun
Número de descargas: 1112 Número de visitas: 678 Citas: 0
Compártelo:
Objective: to investigate the clinical value of vitamin K testing in children with vitamin D deficiency rickets. Methods: fifty children with vitamin D deficiency rickets admitted to our hospital from March 2021 to March 2022 were recruited as the case group using convenience sampling; and an additional 50 children without bone health diseases during the same period of health checkup were selected as the control group. The relevant indexes between the two groups were compared. Results: there were statistically significant differences between the two groups in the level of 25 hydroxyvitamin D3 [25-(OH)D3], the proportion of breastfeeding, and the proportion of preterm birth (p < 0.001). The levels of vitamin K1 and K2 were lower in the case group than in the control group, and the proportion of those with vitamin K1 deficiency and vitamin K2 deficiency were higher than the control group (p < 0.001) . Positive correlations were found between vitamins K1 and K2 and 25-(OH)D3, blood calcium, and blood phosphorus (p < 0.05); artificial feeding, preterm birth, vitamin K1 deficiency, and vitamin K2 deficiency were risk factors for the development of vitamin D deficiency rickets, and the highest AUC of the combination of each index in predicting the occurrence of vitamin D deficiency rickets was 0.951 (95 % CI: 0.910-0.991). Conclusion: preterm birth, artificial feeding, and vitamin K1 and K2 deficiency are independent risk factors for bone metabolism in children with vitamin D-deficiency rickets. And these risk factors have predictive and diagnostic value in the diagnosis and management of vitamin D deficiency rickets.
Palabras Clave: Vitamin D deficiency rickets. Vitamin K. Bone mineral density. Carboxylated osteocalcin.
Pilar Bueno Vargas , Manuel Manzano Martín , Inmaculada López-aliaga , José M.ª López Pedrosa
Cristina Iglesias Blázquez , Francisco Jorquera Plaza , José Antonio De Paz Fernández , Luis Miguel Rodríguez Fernández
Citlalli Álvarez Zaragoza , Edgar Manuel Vásquez-Garibay , Andrea Anaís García Contreras , Alfredo Larrosa-Haro , Enrique Romero-Velarde , Alejandro Rea Rosas , José Luis Cabrales de Anda , Israel Francisco Vega Olea
Elena Crehuá-Gaudiza , Mónica García-Peris , Caterina Calderón , Carmen Jovaní-Casano , María Antonia Moreno , Cecilia Martínez Costa
Antoni García Gabarra
Özlem Özpak Akkuş , Betül Gülşen
Rosa M. Ortega , Ana Isabel Jiménez-Ortega , Rosa María Martínez García , Esther Cuadrado Soto , Aránzazu Aparicio , Ana M. López-Sobaler
Pilar Calmarza , Alejandro Sanz Paris , Clara Berrozpe-Villabona , Alba Gallego Royo , Juan Antonio Domingo Morera , Manuel David Viñuales Aranda
Rui Zhu , Chao-Ren Deng , Shao-Ping Wu