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Introduction: there is a lack of consensus on the benefits of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementations on cognition in dementia and/or Alzheimer’s disease (AD) elderly. Objective: this study presents a systematic review of the results of randomized clinical trials about this topic. The adopted search criteria were randomized clinical trials involving elderly over 65 years of age with no limit to the year of publication of the study. Results: we identified 139 articles, and from the eligible ones a reverse search was conducted. The quality of the trials was assessed using the Jadad scale. Of the four selected studies, three were related to mild to moderate AD elderly, of both genders. Mini Mental State Examination, Alzheimer’s Disease Assessment Scale Cognitive, and Clinical Dementia Rate were the main tests used to assess cognitive performance. Conclusion: EPA and/or DHA supplementations did not affect scores obtained on the cognitive tests. However, supplementation with EPA and/or DHA improved verbal fluency and attention in patients who had only very mild dementia or AD or presented APOEε4 negative genotype. In case of advanced AD elderly patients, EPA and/or DHA supplementations did not reduce cognitive decline rates.
Palabras Clave: N-3 fatty acids. Dietary supplements. Cognition. Alzheimer disease. Dementia.
Nadia Reyna , Rafael Moreno-rojas , Laura Mendoza , Karla Parra , Sergia Linares , Eduardo Reyna , Fernando Cámara-martos
Luciana Rossi , Julio Tirapegui
Virgilio Hernando-Requejo
Norma Isela Vizuet Vega , Teresa Shamah-Levy , Elsa Berenice Gaona Pineda , Lucía Cuevas Nasu , Ignacio Méndez Gómez-humarán
Edilbeto Orozco Arbelaez , José Ramón Banegas , Fernando Rodríguez Artalejo , Esther López García
Jose Enrique De La Rubia Ortí , Carmen Sánchez Álvarez , Pablo Selvi Sabater , Alma María Bueno Cayo , Sandra Sancho Castillo , Mariano Julián Rochina , Iván Hu Yang
Flávia Ivanski , Lizziane de Paula Nascimento , Bárbara Luisa Fermino , Juliana Sartori Bonini , Weber Cláudio Francisco Nunes da Silva , Juliana Maria Silva Valério , Roberta Fabbri , Anne Karine Bosetto , Elizama Gregório
Ana Cantón Blanco , Francisca Margarita Lozano Fuster , María Dolores del Olmo García , María Nuria Virgili-Casas , Carmina Wanden-Berghe , Victoria Avilés , Rosana Ashbaugh Enguídanos , Isabel Ferrero López , Juan B. Molina Soria , Juan Carlos Montejo González , Irene Bretón Lesmes , Julia Álvarez Hernández , José Manuel Moreno Villares
Lucía Arias-Fernández , Esther López García , Ellen A. Struijk , Fernando Rodríguez Artalejo , Alberto Lana Pérez
Luis Guerra-Sánchez , Mar Fresno-Flores , Carmen Martínez-Rincón
Ana M. López-Sobaler , Ana María Lorenzo-Mora , María Dolores Salas-González , África Peral-Suárez , Aránzazu Aparicio , Rosa M. Ortega
Pedro José Carrillo Lopez , Andrés Rosa Guillamón , Pedro Juan Tárraga López , Eliseo García Cantó
Jéssica Martínez Rodríguez , María Roca Fontbona
Blanca M. G. Torres-Mendoza , Genaro Gabriel Ortiz , Lorenzo Sánchez-Romero , Daniela L. C. Delgado-Lara , María T. García Martínez , Mario-Alberto Mireles-Ramírez , José Antonio Cruz Serrano , Fermín Paul Pacheco Moisés
Rosa M. Martínez-García , Ana Isabel Jiménez-Ortega , Ana María Lorenzo-Mora , Laura M. Bermejo
Danitza Díaz Vargas , Marcell Leonario-Rodríguez
Gloria M.A.S. Tedrus , Vania Aparecida Leandro-Merhi , Rafaella Colicigno Rebelo , Bárbara Nunes da Silva
Carolina Morales , Elizabeth Flores Ferro , Johanna Osorio , Fernando Maureira Cid
Ana María Lorenzo-Mora , María del Carmen Lozano-Estevan , Yalda Ghazi , Liliana Guadalupe González-Rodríguez
Antecedentes y objetivo: la endometriosis es un tr...