Número de descargas: 11361 Número de visitas: 1304 Citas: 0
Compártelo:
Aim: considering the frequent consumption of fatrich diets by women of reproductive age, the aim of the present study was to investigate the effects of maternal consumption of a high-fat diet during the perinatal and/ or post-weaning period on the liver parameters and lipid metabolism of young rats. Methods: Wistar female rats were fed a high-fat (H) or control (C) diet during pregnancy and lactation. The offspring were allocated to four groups: Control Control (CC, n = 11), offspring fed a control diet after weaning; Control High-fat (CH, n = 10), offspring fed a high-fat diet after weaning; High-fat High-fat (HH, n = 10), offspring of mothers H fed a high-fat diet after weaning; and High-fat Control (HC, n = 9), offspring of mothers H fed with control diet after weaning. Results and discussion: the food intake did not differ among the groups, however, the relative weight of the adipose tissue was higher in animals from the HC, HH and CH groups (p ≤ 0.005). Liver steatosis was found in the CH and HH animals, which also exhibited hypercholesterolemia (p ≤ 0.05). The levels of the liver enzymes alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (GGT) were higher in the HH group, and the LDL level was higher in the CH group compared to the CC. The consumption of an obesogenic diet during critical periods of development may contribute to the occurrence of visceral obesity, liver steatosis and hypercholesterolemia in adult rats, even in the absence of changes in dietary intake.
Palabras Clave: Critical period of development. High fat diet. Liver. Rats.
Elizângela Gonçalves Schemitt , Josieli Raskopf Colares , Renata Minuzzo Hartmann , María Isabel Morgan-martins , Cláudio Augusto Marroni , M. Jesús Tuñón , Norma Possa Marroni
Ana Fernández-araque , Andrea Giaquinta Aranda , Abel Rojo Aragüés
Pilar Bueno Vargas , Manuel Manzano Martín , Inmaculada López-aliaga , José M.ª López Pedrosa
Fe De Erratas Erratum
Caroline Pinho R. Andrade , Mileda L. T. Portugal , Ellén De Sousa Paz , Paula A. Freitas , Ana Filomena C. S. Daltro , Kaluce G. S. Almondes , Carla Soraya C. Maia , Ariclecio Cunha de Oliveira
Fe De Erratas Fe De Erratas
Aarón Kuri-García , Alejandra González-Reyes , Paola Jazmín Aranda-Vargas , Ulisses Moreno Celis , Carmen Mejía , Teresa García-Gasca , Roberto Augusto Ferríz-Martínez , Karina de la Torre-Carbot , Carlos Saldaña Gutiérrez , Jorge Luis Chávez-Servín
María José Muñoz Alférez , María Robles Rebollo , Jorge Moreno-Fernández , Javier Díaz Castro , María Inmaculada López Aliaga
Bruna Morais Faleiros de Paula , Paula Lumy Takeuchi , Helio Vannucchi
Renato de Souza Abboud , Ilma Cely de Amorim Ribeiro , Vivian Alves Pereira Silva , Lanna Beatriz Neves Corrêa , Gilson Teles Boaventura , Mauricio Alves Chagas
David Betancur Ancona , Luis Chel Guerrero , Arturo Francisco Castellanos Ruelas , Valentino Mukthar Sandoval-Peraza , Rafael Francisco Colin-Flores , Jorge Luis Ble-Castillo , Isela Esther Juárez-Rojop , Juan José Acevedo-Fernández , Patricia Quintana-Owen , Viridiana Olvera Hernández
Areli Carrera-Lanestosa , Juan José Acevedo-Fernández , Maira Rubi Segura-Campos , Rodolfo Velázquez-Martínez , Yolanda Beatriz Moguel-Ordóñez
Heloisa Helena Pessoa Portela-de-Sá , Paula Alexandre de Freitas , Keciany Alves de Oliveira , Yuri de Abreu Gomes-Vasconcelos , Renata Prado Vasconcelos , Said Gonçalves da Cruz Fonseca , Edgleyson Chaves dos Santos , Edivânia Oliveira Bezerra Pontes , Carla Soraya Costa Maia , Andrelina Noronha Coelho-de-Souza , José Henrique Leal-Cardoso , Luciana Catunda Brito , Ariclecio Cunha de Oliveira
Vivian Alves Pereira Silva , Gilson Teles Boaventura , Renato de Souza Abboud , José Antônio Silva Ribas , Mauricio Alves Chagas
Jesús Rojas Jaimes , Midori Chacón-Cruzado , Luis Castañeda-Peláez , Alberto Díaz-Tello
Eryka Maria dos Santos Alves , Nathalia Caroline de Oliveira Melo , Ana Carolina Oliveira Costa , Humberto de Moura Barbosa , Nathália Cavalcanti de Morais Araújo , Gisélia de Santana Muniz , Elizabeth do Nascimento
Ana Cristina Espinoza Gallardo , Antonio López Espinoza , Lucía Cristina Vázquez-Cisneros , Ana Patricia Zepeda-Salvador , Dalila Santillano-Herrera
Luana Cristina Faria Carvalho , Bruna Vidal Dias , Sttefany Viana Gomes , Cláudia Martins Carneiro , Daniela Caldeira Costa
Irving Sosa-Crespo , Luis Chel Guerrero , Juan José Acevedo-Fernández , Elizabeth Negrete León , David Betancur Ancona
Stephan C. Bischoff , William Bernal , Srinivasan Dasarathy , Manuela Merli , Lindsay D. Plank , Tatjana Schütz , Mathias Plauth , Rosa Burgos Peláez , Robin Rivera Irigoin
Shanshan Chen , Yuanye Ma , Haojie Li , Hui Lang , Yongchun Li , Jie Wu , Min Zhou , Yingxin He , Yuan Liu , Erfeng Guo
Antonio Jesús Martínez-Ortega , Ana Piñar Gutiérrez , Carmen Lara-Romero , Pablo Jesús Remón Ruiz , Javier Ampuero-Herrojo , Irene de Lara-Rodríguez , Manuel Romero-Gómez , Pedro P. García Luna , Alfonso Soto-Moreno
Edith Tello-Palma , Martiza Choque-Quispe , Myrian Pacheco-Tanaka , Walter Zamalloa-Cuba , Marleni Valencia-Pacho , Teófilo Donaires-Flores , Elva Macedo-Enriquez , Adelaida Viza-Salas , Amalia Quispe-Romero , Wilbert Paredes-Ugarte , Marco Cossio-Bolaños , Rossana Gómez-Campos
Aida Xochiltl Medina-Urrutia , Esteban Jorge-Galarza , Mohammed El Hafidi , Juan Reyes-Barrera , Araceli Páez-Arenas , Felipe A. Masso-Rojas , Froylan D. Martínez-Sánchez , Ángel R. López-Uribe , María del Carmen González-Salazar , Margarita Torres-Tamayo , Juan Gabriel Juárez-Rojas
Xiaogang Wang , Wei Zhou , Qianqian Song , Ying Xie
Nathália Cavalcanti de Morais Araújo , Vitória Felício Souto , Nathalia Caroline de Oliveira Melo , Morgana Almeida Cavalcante Amorim , Giselia Santana Muniz , Elizabeth do Nascimento
Elena Garicano Vilar , Sara Sanz Rojo , Sara López Oliva , Silvia Martínez , Ana Terrén Lora , Ismael San Mauro Martin
José Antonio Palma-Jacinto , Isela Santiago-Roque , María del Rocío Coutiño-Rodríguez , Omar Elind Arroyo-Helguera
Jianfeng Zhang , Hongyan Duan , Jie Zhang , Hongyan Qiao , Jianwei Jiang
Patricia Quadros dos Santos , Raquel Rocha , Carla Hilário da Cunha Daltro , Sandra Cristina de Souza Andrade , Helma Pinchemel Cotrim
Qian Sun , Huixi Yu , Tao You , Dong Zhang