Gestor Editorial

Nuevo Usuario
Nutrición Hospitalaria 02763 / http://dx.doi.org/10.20960/nh.02763
Resumen| PDF (ENGLISH)

Trabajo Original

Oxidative and inflammatory effects of pulmonary rehabilitation in patients with bronchiectasis. A prospective, randomized study

Casilda Olveira, Eva García-Escobar, Esperanza Doña, Francisco J. Palenque, Nuria Porras, Antonio Dorado, Ana María Godoy, Elezahara Rubio-Martín, Francisco-Javier Bermúdez-Silva, Silvana Y. Romero-Zerbo, Gemma Rojo Martínez, Rocío Martín-Valero, José Abuín Fernández, Gabriel Olveira Fuster

Prepublicado: 2020-01-21
Publicado: 2020-02-12
VOLUMEN 37, NÚM. 1, enero-febrero (2020), PAG. 6-13

Logo Descargas   Número de descargas: 17070      Logo Visitas   Número de visitas: 9026      Citas   Citas: 0

Compártelo:


Background: systemic inflammation and oxidative stress are important factors in the pathogenesis of bronchiectasis. Pulmonary rehabilitation (PR) is recommended for bronchiectasis, but there is no data about its effect on the inflammatory and REDOX status of these patients. Aims: to investigate the effect of PR in non-cystic-fibrosis bronchiectasis (NCFB) patients, and to compare it with the effect of PR plus a hyperproteic oral nutritional supplement (PRS) enriched with beta-hydroxy-beta-methylbutyrate (HMB) on serum inflammatory and oxidative biomarkers. Materials and methods: this was an open randomized, controlled trial. Thirty individuals (65 years old or younger with a body mass index over 18.5, older than 65 years with a body mass index over 20) were recruited from September 2013 to September 2014, and randomly assigned to receive PR or PRS. Total neutrophils, and inflammatory and oxidative biomarker levels were measured at baseline, and then at 3 and 6 months. Results: in the PRS group neutrophil levels were decreased from baseline at 6 months. A significantly different fold change was found between the PR and PRS groups. In the PR group, IL-6 and adiponectin were increased by the end of the study while TNFα levels were decreased from baseline at 6 months. REDOX biomarkers remained stable throughout the study except for 8-isoprostane levels, which were increased from baseline at 6 months in both groups of patients. Conclusions: a PR program induced a pro-oxidative effect accompanied by changes in circulating inflammatory cytokine levels in NCFB patients. Our results would also suggest a possible beneficial effect of the HMB enriched supplement on neutrophil level regulation in these patients. The information provided in this study could be useful for choosing the right therapeutic approach in the management of bronchiectasis.

Palabras Clave: Bronchiectasis. Pulmonary rehabilitation. HMB (beta-hydroxy-beta-methylbutyrate). Oxidative stress. Cytokines.



Mandal P, Hill AT. Bronchiectasis: breaking the cycle of inflammation and infection. Lancet Respir Med 2013;1:e5-6.
DOI: 10.1016/S2213-2600(13)70005-5
Dente FL, Bilotta M, Bartoli ML, Bacci E, Cianchetti S, Latorre M, et al. Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis. Mediators Inflamm 2015;2015:642503.
DOI: 10.1155/2015/642503
Olveira G, Olveira C, Dorado A, Garcia-Fuentes E, Rubio E, Tinahones F, et al. Cellular and plasma oxidative stress biomarkers are raised in adults with bronchiectasis. Clin Nutr 2013;32:112–7.
DOI: 10.1016/j.clnu.2012.06.002
Park HS, Kim SR, Lee YC. Impact of oxidative stress on lung diseases. Respirology 2009;14:27–38.
DOI: 10.1111/j.1440-1843.2008.01447.x
Smith MP. Diagnosis and management of bronchiectasis. CMAJ 2017;189:E828–35.
DOI: 10.1503/cmaj.160830
Guell Rous MR, Diaz Lobato S, Rodriguez Trigo G, Morante Velez F, San Miguel M, Cejudo P, et al. Pulmonary rehabilitation. Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR). Arch Bronconeumol 2014;50:332–44.
Mandal P, Sidhu MK, Kope L, Pollock W, Stevenson LM, Pentland JL, et al. A pilot study of pulmonary rehabilitation and chest physiotherapy versus chest physiotherapy alone in bronchiectasis. Respir Med 2012;106:1647–54.
DOI: 10.1016/j.rmed.2012.08.004
van Zeller M, Mota PC, Amorim A, Viana P, Martins P, Gaspar L, et al. Pulmonary rehabilitation in patients with bronchiectasis: pulmonary function, arterial blood gases, and the 6-minute walk test. J Cardiopulm Rehabil Prev 2012;32:278–83.
DOI: 10.1097/HCR.0b013e3182631314
Lee AL, Hill CJ, Cecins N, Jenkins S, McDonald CF, Burge AT, et al. The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis--a randomised controlled trial. Respir Res 2014;15:44.
DOI: 10.1186/1465-9921-15-44
Hsieh L-C, Chien S-L, Huang M-S, Tseng H-F, Chang C-K. Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit. Asia Pac J Clin Nutr 2006;15:544–50.
Van Koevering M, Nissen S. Oxidation of leucine and alpha-ketoisocaproate to beta-hydroxy-beta-methylbutyrate in vivo. Am J Physiol 1992;262:E27-31.
DOI: 10.1152/ajpendo.1992.262.1.E27
Cruz-Jentoft AJ. Beta-hydroxy-beta-methyl butyrate (HMB): From experimental data to clinical evidence in sarcopenia. Curr Protein Pept Sci 2017.
DOI: 10.2174/1389203718666170529105026
van Helvoort HAC, Heijdra YF, de Boer RCC, Swinkels A, Thijs HMH, Dekhuijzen PNR. Six-minute walking-induced systemic inflammation and oxidative stress in muscle-wasted COPD patients. Chest 2007;131:439–45.
DOI: 10.1378/chest.06-1655
Mercken EM, Calvert LD, Singh SJ, Hageman GJ, Schols AM, Steiner MC. Dichloroacetate modulates the oxidative stress and inflammatory response to exercise in COPD. Chest 2009;136:744–51.
DOI: 10.1378/chest.08-2890
Rodriguez DA, Kalko S, Puig-Vilanova E, Perez-Olabarria M, Falciani F, Gea J, et al. Muscle and blood redox status after exercise training in severe COPD patients. Free Radic Biol Med 2012;52:88–94.
DOI: 10.1016/j.freeradbiomed.2011.09.022
Nemoto K, Oh-Ishi S, Itoh M, Saito T, Ichiwata T. Urinary 8-hydroxydeoxyguanosine is a potential indicator for estimating pulmonary rehabilitation-induced oxidative stress in COPD patients. Tohoku J Exp Med 2014;233:197–204.
DOI: 10.1620/tjem.233.197
Olveira G, Olveira C, Dona E, Palenque FJ, Porras N, Dorado A, et al. Oral supplement enriched in HMB combined with pulmonary rehabilitation improves body composition and health related quality of life in patients with bronchiectasis (Prospective, Randomised Study). Clin Nutr 2016;35:1015–22.
DOI: 10.1016/j.clnu.2015.10.001
Doña E, Olveira C, Palenque FJ, Porras N, Dorado A, Martín-Valero R, et al. Pulmonary rehabilitation only versus with nutritional supplementation in patients with bronchiectasis: a randomized controlled trial. J Cardiopulm Rehabil Prev 2018;Jun.
DOI: 10.1097/HCR.0000000000000341
Craig CL, Marshal AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. International Physical Activity Questionnaire: 12-Country Reliability and Validity. Med Sci Sport Exerc 2003;35:1381–95.
DOI: 10.1249/01.MSS.0000078924.61453.FB
Doña E, Olveira C, Palenque FJ, Dorado A, Martín-Valero R, Olveira G. The effect od pulmonary rehabilitation associated with nutritional supplementation on physical activity in patients with bronchiectasis: Randomized trial. Rev Esp Patol Torac 2017;29:167–75.
Olveira G, Olveira C, Gaspar I, Porras N, Martín-Núñez G, Rubio E, et al. Fat-free mass depletion and inflammation in patients with bronchiectasis. J Acad Nutr Diet 2012;112:1999–2006.
DOI: 10.1016/j.jand.2012.08.013
Marco E, Ramírez-Sarmiento AL, Coloma A, Sartor M, Comin-Colet J, Vila J, et al. High-intensity vs. sham inspiratory muscle training in patients with chronic heart failure: a prospective randomized trial. Eur J Heart Fail 2013;15:892–901.
DOI: 10.1093/eurjhf/hft035
Garcia-Fuentes E, Murri M, Garrido-Sanchez L, Garcia-Serrano S, García-Almeida JM, Moreno-Santos I, et al. PPARgamma expression after a high-fat meal is associated with plasma superoxide dismutase activity in morbidly obese persons. Obesity (Silver Spring) 2010;18:952–8.
DOI: 10.1038/oby.2009.314
Corp IBM. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY 2011.
Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K. Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev 2002;8:6–48.
Bartlett DB, Shepherd SO, Wilson OJ, Adlan AM, Wagenmakers AJM, Shaw CS, et al. Neutrophil and Monocyte Bactericidal Responses to 10 Weeks of Low-Volume High-Intensity Interval or Moderate-Intensity Continuous Training in Sedentary Adults. Oxid Med Cell Longev 2017;2017:8148742.
DOI: 10.1155/2017/8148742
Tenorio TRS, Balagopal PB, Andersen LB, Ritti-Dias RM, Hill JO, Lofrano-Prado MC, et al. Effect of Low- Versus High-Intensity Exercise Training on Biomarkers of Inflammation and Endothelial Dysfunction in Adolescents With Obesity: A 6-Month Randomized Exercise Intervention Study. Pediatr Exerc Sci 2017:1–10.
DOI: 10.1123/pes.2017-0067
Nunes EA, Lomax AR, Noakes PS, Miles EA, Fernandes LC, Calder PC. beta-Hydroxy-beta-methylbutyrate modifies human peripheral blood mononuclear cell proliferation and cytokine production in vitro. Nutrition 2011;27:92–9.
DOI: 10.1016/j.nut.2009.12.008
Wojcik R, Malaczewska J, Siwicki AK, Micinski J, Zwierzchowski G. The effect of beta-hydroxy-beta-methylbutyrate (HMB) on the proliferative response of blood lymphocytes and the phagocytic activity of blood monocytes and granulocytes in calves. Pol J Vet Sci 2013;16:567–9.
DOI: 10.2478/pjvs-2013-0078
van Helvoort HAC, van de Pol MHJ, Heijdra YF, Dekhuijzen PNR. Systemic inflammatory response to exhaustive exercise in patients with chronic obstructive pulmonary disease. Respir Med 2005;99:1555–67.
DOI: 10.1016/j.rmed.2005.03.028
Xie J, Yang X-Y, Shi J-D, Deng X-Q, Long W. A new inflammation marker of chronic obstructive pulmonary disease-adiponectin. World J Emerg Med 2010;1:190–5.
Townsend JR, Fragala MS, Jajtner AR, Gonzalez AM, Wells AJ, Mangine GT, et al. beta-Hydroxy-beta-methylbutyrate (HMB)-free acid attenuates circulating TNF-alpha and TNFR1 expression postresistance exercise. J Appl Physiol 2013;115:1173–82.
DOI: 10.1152/japplphysiol.00738.2013
Kraemer WJ, Hooper DR, Szivak TK, Kupchak BR, Dunn-Lewis C, Comstock BA, et al. The addition of beta-hydroxy-beta-methylbutyrate and isomaltulose to whey protein improves recovery from highly demanding resistance exercise. J Am Coll Nutr 2015;34:91–9.
DOI: 10.1080/07315724.2014.938790
Laviolette L, Lands LC, Dauletbaev N, Saey D, Milot J, Provencher S, et al. Combined effect of dietary supplementation with pressurized whey and exercise training in chronic obstructive pulmonary disease: a randomized, controlled, double-blind pilot study. J Med Food 2010;13:589–98.
DOI: 10.1089/jmf.2009.0142
Sugawara K, Takahashi H, Kashiwagura T, Yamada K, Yanagida S, Homma M, et al. Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD. Respir Med 2012;106:1526–34.
DOI: 10.1016/j.rmed.2012.07.001
Sugawara K, Takahashi H, Kasai C, Kiyokawa N, Watanabe T, Fujii S, et al. Effects of nutritional supplementation combined with low-intensity exercise in malnourished patients with COPD. Respir Med 2010;104:1883–9.
DOI: 10.1016/j.rmed.2010.05.008
de Godoy I, Donahoe M, Calhoun WJ, Mancino J, Rogers RM. Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients. Am J Respir Crit Care Med 1996;153:633–7.
DOI: 10.1164/ajrccm.153.2.8564110
Broekhuizen R, Wouters EFM, Creutzberg EC, Schols AMWJ. Raised CRP levels mark metabolic and functional impairment in advanced COPD. Thorax 2006;61:17–22.
DOI: 10.1136/thx.2005.041996
Wood LG, Fitzgerald DA, Gibson PG, Cooper DM, Collins CE, Garg ML. Oxidative stress in cystic fibrosis: dietary and metabolic factors. J Am Coll Nutr 2001;20:157–65.
DOI: 10.1080/07315724.2001.10719028
Couillard A, Maltais F, Saey D, Debigare R, Michaud A, Koechlin C, et al. Exercise-induced quadriceps oxidative stress and peripheral muscle dysfunction in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003;167:1664–9.
DOI: 10.1164/rccm.200209-1028OC

Artículos Relacionados:

Trabajo Original: Protection by polyphenol extract from olive stones against apoptosis produced by oxidative stress in human neuroblastoma cells

Ernesto Cortés-Castell , Carmen Veciana-galindo , Luis Torró-montell , Antonio Palazón-Bru , Elia Sirvent-Segura , Vicente Gil-guillén , Mercedes Rizo-baeza

Publicado: 2016-02-17 / http://dx.doi.org/10.20960/nh.39
Resumen | PDF

Trabajo Original: Efecto de la glutamina en el estrés oxidativo y la inflamación en un modelo de rata con insuficiencia hepática fulminante

Elizângela Gonçalves Schemitt , Josieli Raskopf Colares , Renata Minuzzo Hartmann , María Isabel Morgan-martins , Cláudio Augusto Marroni , M. Jesús Tuñón , Norma Possa Marroni

Publicado: 2016-05-16 / http://dx.doi.org/10.20960/nh.92
Resumen | PDF

Trabajo Original: Factores de riesgo relacionados con los hábitos de vida en pacientes con patología osteomuscular

María Teresa Nestares , Macarena Salinas , Carlos De Teresa , Javier Díaz Castro , Jorge Moreno-Fernández , Magdalena López-frías

Publicado: 2016-06-23 / http://dx.doi.org/10.20960/nh.237
Resumen | PDF

Trabajo Original: Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease

Sergio Cuellar-rufino , Mónica Navarro-meza , Pablo García-solís , Irene Xochihua-rosas , Omar Arroyo-helguera

Publicado: 2016-08-12 / http://dx.doi.org/10.20960/nh.460
Resumen | PDF

Revisión: Telómeros y calidad de la dieta

Amelia Marti , Raquel Echeverría , Lydia Morell-azanza , Ana Ojeda-rodríguez

Publicado: 2017-04-06 / http://dx.doi.org/10.20960/nh.1181
Resumen | PDF

Trabajo Original: Vitamin D insufficiency/deficiency and its association with cardiometabolic risk factors in Brazilian adolescents

Dayana Joyce Marques Queiroz , Alexandre Sérgio Silva , Alcides da Silva Diniz , Alice Teles de Carvalho , Eduarda Pontes dos Santos Araújo , Juliana Padilha Ramos Neves , Lavoisiana Lacerda de Lucena , Lydiane Tavares Toscano , Maria da Conceição Rodrigues Gonçalves

Publicado: 2018-03-06 / http://dx.doi.org/10.20960/nh.1884
Resumen | PDF

Trabajo Original: Association of the rs10830963 polymorphism in MTNR1B with fasting glucose, serum adipokine levels and components of metabolic syndrome in adult obese subjects

Daniel de Luis Román , David Primo , Rocio Aller , Olatz Izaola

Publicado: 2018-04-25 / http://dx.doi.org/10.20960/nh.2013
Resumen | PDF

Trabajo Original: Green tea supplementation improves oxidative stress biomarkers and modulates IL-6 circulating levels in obese women

Natália Yumi Noronha , Marcela Augusta De Souza Pinhel , Carolina Ferreira Nicoletti , Driele Cristina Gomes Quinhoneiro , Vitor Caressato Pinhanelli , Bruno Affonso Parenti Oliveira , Cristiana Cortes-Oliveira , Heitor Bernardes Pereira Delfino , Leticia Santana Wolf , Fabiani Gai Frantz , Júlio Sergio Marchini , Carla Barbosa Nonino

Publicado: 2018-06-20 / http://dx.doi.org/10.20960/nh.2159
Resumen | PDF

Trabajo Original: Influencia del entrenamiento en fútbol sobre parámetros de estrés oxidativo en eritrocitos

Jesús Siquier Coll , Diego Muñoz Marín , Francisco Javier Grijota Pérez , Ignacio Bartolomé Sánchez , María Concepción Robles Gil , Julio Montero Arroyo , Marcos Maynar Mariño

Publicado: 2018-10-31 / http://dx.doi.org/10.20960/nh.02381
Resumen | PDF

Trabajo Original: Cytokines and body adiposity in young female undergraduate students

Deyliane Aparecida de Almeida Pereira , Lucimar Aguiar da Silva , Silvia Oliveira Lopes , Sarah Aparecida Vieira Ribeiro , Sylvia do Carmo Castro Franceschini , Silvia Eloiza Priore

Publicado: 2019-09-06 / http://dx.doi.org/10.20960/nh.02860
Resumen | PDF

Trabajo Original: Relación entre la obesidad central y el estrés oxidativo en mujeres premenopáusicas versus posmenopáusicas

Adriana Rodríguez-San Nicolás , Martha A. SÁnchez-RodrÍguez , Mariano Zacarías-Flores , Elsa Correa-Muñoz , Víctor Manuel Mendoza-Núñez

Publicado: 2019-02-20 / http://dx.doi.org/10.20960/nh.02552
Resumen | PDF

Trabajo Original: Efecto de una dieta de patrón mediterráneo en la respuesta metabólica secundaria a la pérdida de peso; papel del polimorfismo de un único nucleótido (rs16147) del gen del neuropéptido Y

David Primo Martín , Olatz Izaola , Juan José López , Emilia Gómez Hoyos , Ana Ortolá Buigues , Esther Delgado , Gonzalo Díaz , Beatriz Torres Torres , Daniel de Luis Román

Publicado: 2019-11-13 / http://dx.doi.org/10.20960/nh.02941
Resumen | PDF

Trabajo Original: In-vivo assessment of the protection of β-glucans of Pleurotus ostreatus against oxidative stress caused by acrylamide intake (part II)

Blanca Rosa Aguilar Uscanga , Adriana Cavazos Garduño , Josué R. Solís Pacheco , Flavio Sandoval-Garcia , Rosa Elena Navarro Hernández , Julio César Serrano Niño

Publicado: 2020-04-08 / http://dx.doi.org/10.20960/nh.03117
Resumen | PDF

Trabajo Original: Efecto positivo de un suplemento de propóleo sobre el perfil lipídico, la glucemia y el estado antioxidante hepático en un modelo animal experimental

Maria Jesus Lisbona-González , Candela Reyes Botella , Esther Muñoz Soto , Marta Vallecillo-Rivas , Jorge Moreno Fernández , Javier Díaz Castro

Publicado: 2020-02-28 / http://dx.doi.org/10.20960/nh.03060
Resumen | PDF

Trabajo Original: Análisis del perfil bioquímico y antropométrico, y de la ingesta de micronutrientes antioxidantes en pacientes con hipertensión arterial resistente

Priscila Stefani Vallejos Vildoso , Jorge da Silva Pinho Jr , Ana Paula Azevedo de Mattos , Gabrielle de Souza Rocha , Sergio Girão Barroso , Grazielle Vilas Boas Huguenin , Andréa Cardoso de Matos

Publicado: 2019-11-29 / http://dx.doi.org/10.20960/nh.02962
Resumen | PDF

Trabajo Original: Serum concentration of vitamin A and its relationship with body adiposity, oxidative stress, and cardiovascular risk in women with recommended dietary intake of vitamin A

Claudia Bento , Andrea Matos , Adryana Cordeiro , Andréa Ramalho

Publicado: 2020-04-22 / http://dx.doi.org/10.20960/nh.03129
Resumen | PDF

Trabajo Original: Capacidad antioxidante total de la dieta de las mujeres gestantes de la Comunidad de Madrid

Rocío Angélica Salinas Osornio , María Victorina Aguilar-Vilas , Antonio Becerra-Fernández , Laura González López , Blanca Miriam Torres-Mendoza

Publicado: 2020-10-07 / http://dx.doi.org/10.20960/nh.03384
Resumen | PDF

Revisión: Hipótesis sobre las conexiones entre COVID-19 severo en niños y nutrición: una revisión narrativa

Ximena León-Lara , Ariana Vargas-Castillo , Azalia Avila-Nava , Martha Guevara-Cruz , Aurora E Serralde Zúñiga , Isabel Medina-Vera

Publicado: 2020-11-25 / http://dx.doi.org/10.20960/nh.03452
Resumen | PDF

Trabajo Original: Relationship between BsmI polymorphism and VDR gene methylation profile, gender, metabolic profile, oxidative stress, and inflammation in adolescents

Lavoisiana Lacerda de Lucena , Alexandre Sérgio Silva , Rayner Anderson Ferreira do Nascimento , Darlene Camati Persuhn , Juliana Padilha Ramos Neves , Maria José Carvalho Costa , Dayana Joyce Marques Queiroz , Rafaela Lira Formiga Covalcanti de Lima , Raquel Patrícia Ataíde de Lima , Maria Paula de Paiva , Naila Francis Paulo de Oliveira , Maria da Conceição Rodrigues Gonçalves

Publicado: 2020-10-06 / http://dx.doi.org/10.20960/nh.03383
Resumen | PDF

Trabajo Original: Interleukin-6 and triceps skinfold are associated with severity/cancer stage in newly-diagnosed colorectal cancer patients

Samara Bomfim Gomes Campos , Amylly Sanuelly da Paz Martins , Anne Karolyne dos Santos , Marília Oliveira Fonseca Goulart , Fabiana Andréa Moura

Publicado: 2021-05-13 / http://dx.doi.org/10.20960/nh.03696
Resumen | PDF

Artículo Especial: The reduction of the metabolyc syndrome in Navarra-Spain (RESMENA-S) study; a multidisciplinary strategy based on chrononutrition and nutritional education, together with dietetic and psychological control

Publicado: 2021-06-23 / http://dx.doi.org/
Resumen | PDF

Revisión: Antioxidantes y diabetes mellitus: revisión de la evidencia

Publicado: 2021-06-23 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Adipocitoquinas circulantes en obesos mórbidos, relación con factores de riesgo cardiovascular y parámetros antropométricos

Publicado: 2021-06-23 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Influencia de los carotenoides sobre los marcadores de riesgo cardiometabólico en mujeres peri y posmenopáusicas

Aina Tomás Luiz , Gala Martín Pozuelo , Inmaculada González Navarro , Laura Elvira Torales , Helena Ponce , Rocío González Barrio , Javier García Alonso , María Jesús Periago

Publicado: 2021-03-25 / http://dx.doi.org/10.20960/nh.03624
Resumen | PDF

Trabajo Original: Roles of G1359A polymorphism of the cannabinoid receptor gene (CNR1) on weight loss and adipocytokines after a hypocaloric diet

Publicado: 2021-06-24 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Factors associated with oxidative stress in women with breast cancer

Publicado: 2021-06-25 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Mineral and/or milk supplementation of fruit beverages helps in the prevention of H2O2-induced oxidative stress in Caco-2 cells

Publicado: 2021-06-25 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Allelic frequency of G380A polymorphism of tumor necrosis factor alpha gene and relation with cardiovascular risk factors and adipocytokines in obese patients

Publicado: 2021-06-28 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Dietary intake and oxidative stress in breast cancer: before and after treatments

Publicado: 2021-06-28 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Efecto de la suplementación con antioxidantes sobre el estrés oxidativo y la calidad de vida durante el tratamiento oncológico en pacientes con cáncer cérvico uterino

Publicado: 2021-06-28 / http://dx.doi.org/
Resumen | PDF

Revisión: Meta-análisis del papel del licopeno en la diabetes mellitus tipo 2

Publicado: 2021-07-02 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Problemática nutricional en fumadores y fumadores pasivos

Rosa M. Ortega , Ana Isabel Jiménez-Ortega , Rosa María Martínez García , Ana María Lorenzo-Mora , María del Carmen Lozano-Estevan

Publicado: 2021-07-20 / http://dx.doi.org/10.20960/nh.03794
Resumen | PDF

Trabajo Original: Relación del polimorfismo rs9939609 del gen FTO con factores de riesgo cardiovascular y niveles de adipocitoquinas en pacientes con obesidad mórbida

Publicado: 2021-09-29 / http://dx.doi.org/
Resumen | PDF

Revisión: The role of hyperglycemia in the induction of oxidative stress and inflammatory process

Publicado: 2021-10-04 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Influence of G1359A polimorphysm of the cannabinoid receptor gene (CNR1) on insulin resistance and adipokines in patients with non alcoholic fatty liver disease

Publicado: 2021-10-05 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Enzyme activity of superoxide dismutase and zincemia in women with preeclampsia

Publicado: 2021-10-19 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Estrés oxidativo; estudio comparativo entre un grupo de población normal y un grupo de población obesa mórbida

Publicado: 2021-10-25 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Effects of parenteral fish oil lipid emulsions on colon morphology and cytokine expression after experimental colitis

Publicado: 2021-10-25 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Relación del estrés oxidativo y la pérdida de peso obtenida en pacientes obesos mórbidos mediante cirugía bariátrica con la técnica del cruce duodenal

Publicado: 2021-10-26 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Peroxidación de lípidos y la respuesta del sistema de defensa antioxidante en el diabético tipo 2 obeso en comparación al diabético tipo 2 sin obesidad

Publicado: 2021-10-28 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Prevalence of metilentetrahidrofolate reductase C677T polymorphism, consumption of vitamins B6, B9, B12 and determination of lipidic hydroperoxides in obese and normal weight Mexican population

Publicado: 2021-10-29 / http://dx.doi.org/
Resumen | PDF

Revisión: Micronutrients influencing the immune response in leprosy

Publicado: 2021-11-02 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Papel del polimorfismo RS 6923761 del receptor glucagon-like peptide 1 receptor sobre el peso, riesgo cardiovascular y niveles de adipocitoquinas en pacientes con obesidad mórbida

Publicado: 2021-11-03 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Interaction between mercury (Hg), arsenic (As) and selenium (Se) affects the activity of glutathione S-transferase in breast milk; possible relationship with fish and shellfish intake

Publicado: 2021-11-04 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Defensas antioxidantes en leche materna en relación al número de gestas y a la edad de las madres

Publicado: 2021-11-08 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Influence of magnesium on biochemical parameters of iron and oxidative stress in patients with type 2 diabetes

Publicado: 2021-11-08 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Association between ferritin, high sensitivity c-reactive protein (hsCRP) and relative abundance of Hepcidin mRNA with the risk of type 2 diabetes in obese subjects

Publicado: 2021-11-08 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Effect of l-arginine supplementation on insulin resistance and adipocitokines levels in head and neck cancer non diabetic patients after surgery

Publicado: 2021-11-15 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program

Publicado: 2021-11-15 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Indicadores de estrés oxidativo en suero y comportamiento alimentario en adultos de una zona rural de Jalisco, México

Publicado: 2021-11-18 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Effects of dietary supplementation with lemon verbena extracts on serum inflammatory markers of multiple sclerosis patients

Publicado: 2021-11-24 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: High-protein diet induces oxidative stress in rat brain: protective action of high-intensity exercise against lipid peroxidation

Publicado: 2021-11-25 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Glycemic Control and Oxidative Stress Markers and their relationship with the Thioredoxin Interacting Protein (TXNIP) gene in Type 2 Diabetic patients

Publicado: 2021-11-25 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Factores que inciden el daño oxidativo en niños con obesidad: estudio piloto

Publicado: 2021-11-26 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Purine nucleoside phosphorylase and the enzymatic antioxidant defense system in breast milk from women with different levels of arsenic exposure

Publicado: 2021-11-30 / http://dx.doi.org/
Resumen | PDF

Revisión: Inflamación y obesidad (lipoinflamación)

Publicado: 2021-11-30 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Reduction of serum advanced glycation end-products with a low calorie Mediterranean diet

Publicado: 2021-11-30 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Fish oil and vitamin E change lipid profiles and anti-LDL-antibodies in two different ethnic groups of women transitioning through menopause

Publicado: 2021-12-01 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Effect of long term intake of white tea on acute oxidative stress in rats

Publicado: 2022-01-11 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Relationship between zincemia, superoxide dismutase activity and marker of oxidative stress in women with breast cancer

Publicado: 2022-01-12 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Macronutrient intake is correlated with dyslipidemia and low-grade inflammation in childhood obesity but mostly in male obese

Publicado: 2022-01-12 / http://dx.doi.org/
Resumen | PDF

Revisión: Potencial antioxidante de la miel de Melipona beecheii y su relación con la salud: una revisión

Publicado: 2022-01-19 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Glutathione peroxidase-1 Pro200Leu polymorphism (rs1050450) is associated with morbid obesity independently of the presence of prediabetes or diabetes in women from Central Mexico

Publicado: 2022-01-19 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Epitope-based vaccine for the treatment of Der f 3 allergy

Publicado: 2022-01-21 / http://dx.doi.org/
Resumen | PDF

Trabajo Original: Dietary fish oil increases catalase activity in patients with probable Alzheimer’s disease

Blanca M. G. Torres-Mendoza , Genaro Gabriel Ortiz , Lorenzo Sánchez-Romero , Daniela L. C. Delgado-Lara , María T. García Martínez , Mario-Alberto Mireles-Ramírez , José Antonio Cruz Serrano , Fermín Paul Pacheco Moisés

Publicado: 2022-04-08 / http://dx.doi.org/10.20960/nh.04153
Resumen | PDF

Trabajo Original: Vitamin D levels and their association with oxidative stress and inflammation markers in patients with cystic fibrosis

Dayana Joyce Marques Queiroz , Alexandre Sérgio Silva , Celso Costa da Silva Júnior , Darlene Camati Persuhn , Alcides da Silva Diniz , Rafaela Lira Formiga Cavalcanti de Lima , Maria Paula de Paiva , Constantino Giovanni Braga Cartaxo , Patricia Gomes de Matos Bezerra , Mateus Duarte Ribeiro , Maria da Conceição Rodrigues Gonçalves

Publicado: 2022-05-23 / http://dx.doi.org/10.20960/nh.04253
Resumen | PDF

Trabajo Original: Evaluación del efecto in vitro de extractos intra y extracelulares de Lactobacillus contra la genotoxicidad y el estrés oxidativo causado por la acrilamida

Maria Goretti Reyes López , Adriana Cavazos Garduño , Nancy Elizabeth Franco Rodríguez , Jorge Manuel Silva Jara , Julio César Serrano Niño

Publicado: 2022-05-15 / http://dx.doi.org/10.20960/nh.04241
Resumen | PDF

Trabajo Original: Efecto de un multivitamínico sobre la resistencia a la insulina, inflamación y estrés oxidante en un modelo de obesidad inducida en ratas Wistar

José Antonio Palma-Jacinto , Isela Santiago-Roque , María del Rocío Coutiño-Rodríguez , Omar Elind Arroyo-Helguera

Publicado: 2023-01-31 / http://dx.doi.org/10.20960/nh.04621
Resumen | PDF

Artículos más populares

Revisión: La importancia de la alimentación en la prevención de la endometriosis: revisión sistemática

Antecedentes y objetivo: la endometriosis es un tr...

Publicado: 2023-08-30
Resumen | PDF

Carta Editor: Revisión sistemática frente a “scoping review”: guía para una elección informada en las investigaciones

Publicado: 2024-05-19
Resumen | PDF

Editado en Madrid por:
Diseño y Desarrollo web Im3diA comunicación

Una cookie o galleta informática es un pequeño archivo de información que se guarda en su navegador cada vez que visita nuestra página web. La utilidad de las cookies es guardar el historial de su actividad en nuestra página web, de manera que, cuando la visite nuevamente, ésta pueda identificarle y configurar el contenido de la misma en base a sus hábitos de navegación, identidad y preferencias. Las cookies pueden ser aceptadas, rechazadas, bloqueadas y borradas, según desee. Ello podrá hacerlo mediante las opciones disponibles en la presente ventana o a través de la configuración de su navegador, según el caso. En caso de que rechace las cookies no podremos asegurarle el correcto funcionamiento de las distintas funcionalidades de nuestra página web. Más información en el apartado “POLÍTICA DE COOKIES” de nuestra página web.

Rechazar